On May 20, the international academic journals published online Journal of Virology, Chinese Academy of Sciences Shanghai Pasteur Institute of infection immunity and vaccine research group research paper Repeated Low-dose Influenza Virus Infection Causes Severe Disease in Mice:a Model for Vaccine Evaluation.
Influenza is an acute respiratory infection caused by the influenza virus, mainly through droplets, human contact and contact with contaminated spread, with a high incidence of infectious, and likely to cause outbreaks, posed a serious public health threat to humanity.
Influenza vaccines are effective measures to prevent and control the epidemic. Study on effectiveness evaluation of new influenza vaccines and protective effect of common animals (mice, ferrets, etc) model as a means of infection. In previous influenza infection models, often using a one-time high dose of influenza virus infection. During the process of natural infection, influenza virus in some space and time may be repeated contact with infected people, and each contact of the infected virus doses may be very limited. Therefore, closer to the natural animal models of infection cases of influenza infection, influenza virus infection of the host immune pathological studies on vaccines or antiviral drug research and development is of great significance.
Study on anti-infection immunity of Shanghai Pasteur vaccine, an assistant researcher Song Yufeng, doctor Wang and other researchers under the direction of Zhou Dongming, established a mouse model with low dose repeated infection of the flu virus, and studied the pathology of the model, the immune response, as well as in the commercialization of vaccine potency evaluation applications. Studies have found that low dose repeated infections of influenza virus in mice accumulate higher levels of virus titer, causing more severe pathology, quickly leads to weight loss and death. Also, this model can induce higher inflammasomes response. In addition, the study found that the traditional inactivated trivalent influenza vaccine can protect mice from single large doses of flu virus infection, but does not protect against influenza virus infection low dose repeated attacks, suggesting that the animal model in evaluation of vaccine effectiveness has very good value. The study is the first to set up a flu-like infection animal model for influenza research to provide a true and effective platform.
The research, Chinese Academy of Sciences, "Science and technology innovation plan", "hundreds of people plan", Shanghai Pasteur Foundation, the National Natural Science Foundation of China Youth Science Fund and Shanghai Science and Technology Commission "plan of action for science and technology innovation" laboratory animal research science and technology support projects in the field, such as financial support.