From The Camel? Deadly Infectious MERS Viruses Of The Past And Present

Recently, on the MERS virus (respiratory syndrome corona virus in the Middle East), another outbreak again attracted the concern of health systems around the world, caused by the Middle East "respiratory syndrome" is an acute, severe respiratory disease, initially and primarily in Saudi Arabia, the Middle East and then spread to other countries. As of June 2, 2015, MERS cumulative number of viruses in the world has reached 1157, in which 434 cases death. So far, there is no vaccine for MERS or specific content, that the lethality of the virus as much as 40%. The end of May this year, Korea the first imported MERS cases; in two weeks, the number of new infections has shot up to 18. Last week, China's first imported MERS cases also.

Recent scientific studies show: MERS virus might come from camels, direct contact with infected camels may have caused the initial infection of humans.

By the Netherlands National Institute of public health and Environment Institute, the Netherlands Rotterdam Erasmus medical centre and Germany University of Bonn Medical Center confirmed joint study on the source of the virus, is a coronavirus Spike protein major structural protein of the virus infecting a host cell. Spike proteins in biological structures can be classified as S1 and S2, two-part (subunit). In 2013, Reusken MERS for human use, such as viruses, SARS virus and human coronavirus OC43 S1 subunits made of protein chip detection by 350 animal serum samples and test results were verified by virus neutralization test, results showed that Dromedary MERS virus infection. About the same time, Hong Kong University, the Chinese Academy of Sciences and the University of Tokyo structural Virology and Immunology laboratory, Egypt National Research Center and United States Saint Jude children's research hospital Perera and others with fake virus Spike protein particle was detected in 1343 of serum samples as well as 625 animal serum samples, conclusion Dromedary was probably MERS virus host.

In 2014, Haagmans et al detected by RT-PCR method in the Dromedary nasal swabs (usually as a collection, exfoliative cells of microorganisms or secretion of medical examination) and MERS in the sample virus similar genes. Subsequently, Briese et Dromedary camels live virus nasal swab samples were recovery, training, and whole-genome sequencing to find: Dromedary sources of virus sequences and sources of MERS virus sequences are almost identical. Moreover, the same camel may be MERS virus infected.

Regular contact with camel middle-aged subclinical infection may be infection of MERS, MERS viruses to those never exposed to the camel's ordinary people.
2015, m u ller, people collection has Saudi Arabia of 10,009 name people, and 87 name camel breeder and 140 name slaughterhouse staff of serum, and take has series of biology experiment method, as ELISA: (package was HEK293T cell expression of S1 restructuring protein), and immune fluorescent method (with VeroB4 cell expression MERS-CoV Spike full length protein) and empty spot reduced in the and experiment to detection serum in the of anti-MERS virus of antibody. Results show that the camel breeders and anti-MERS virus antibody in serum of slaughterhouse staff the seropositivity rates were higher than average 15 and 23 times, and average about 10 years younger than the admitted patients with MERS. However, these seropositive individuals never showing serious symptoms of MERS.

At this point, despite MERS cannot be ruled out the presence of the virus in other host, but we can be sure: camel Dromedary and the regular contact who is MERS virus infection. At present, MERS is still on the rise, find the MERS virus early detection methods, exploring the invasion mechanisms and screening antiviral drugs will be the necessary means for infectious disease research. Now, the commercialization of research reagent products has been successfully developed in China and listed (such as MERS virus recombinant Spike protein, NP recombinant protein, antibody, such as gene expression and cell lysate, meaning snub China, Beijing). Hope that with the progress of scientific research methods and tools, we can develop as soon as possible against MERS and other faster means of detection and treatment of the deadly infectious disease.