Recently, from the Netherlands researchers published in the journal cell reports online of their latest research results. They have discovered antifungal drug itraconazole resistance (ITZ) can function as a broad spectrum inhibitors of intestinal viruses. The study on development of itraconazole in the treatment of intestinal viral diseases is significant to the new role.
Points out that ITZ through targeted oxidation sterol-binding protein (OSBP) and OSBP-related protein 4 (ORP4) inhibiting viral RNA replication and found that OSBP/ORP4 specific antagonist OSW-1 inhibits intestinal viral replication. Experiments prove that knocking OSBP expression inhibits intestinal virus replication, OSBP or the ORP4 expression can be offset by ITZ and OSW-1 the inhibition of viral replication. ITZ can combine OSBP and restrain its cholesterol and phosphatidyl inositol 4-phosphate transport, might disrupt the virus membrane changes induced by this cell formation has important implications in viral replication, at the same time, researchers found that ITZ also inhibits hepatitis c virus replication.
To sum up, researchers found that the itraconazole in addition to antifungal antitumor properties, can also be used as a broad spectrum inhibitors of intestinal viruses play a role. This development of itraconazole in the treatment of viral diseases of the gut is important.